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Figure 2 | BMC Neuroscience

Figure 2

From: Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs

Figure 2

Proteolytic cleavage of the SREBP2 transcription factor. A) The semi-quantitative M/P-ratio of the mature transcriptionally active 60–70 kDa fragment (M) and the SREBP2 120 kDa inactive precursor (P) as a measurement of the degree of SREBP2 activation following antipsychotic drug treatment. The results are representative of two independent western blot experiments. In agreement with the gene expression results, haloperidol, chlorpromazine, clozapine and olanzapine all induced marked SREBP2 cleavage. B) The effect of clozapine on 25-hydroxycholesterol (25-HC) -induced repression of endogenous SREBP-2 activity in GaMg cells. Clozapine (30 μM) significantly counteracts the SREBP2 repression induced by 25-HC (1 μg/ml) after 2 hours of incubation. The results are representative of two independent experiments.

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BMC Neuroscience

ISSN: 1471-2202

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