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Figure 6 | BMC Neuroscience

Figure 6

From: Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric

Figure 6

Scatter plot of X-Gal staining scores for individual retinas from aged DBA/2J R3/+ mice compared to aged C57BL/6R3/+ animals. Loss of X-Gal staining correlates to the loss of retinal ganglion cells [27]. A majority of DBA/2J mice older than 10.5 months exhibit reduced staining, relative to younger animals (closed circles). Although these mice develop progressively more damage as they age, there is a high degree of variability in the amount of damage exhibited by mice at the older ages. Retinal disease is associated with the DBA/2J genetic background, since no cell loss was observed in C57BL/6 mice (open circles) at any age examined.

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