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Figure 5 | BMC Neuroscience

Figure 5

From: Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric

Figure 5

Whole mounts of retinas taken from 13 month old DBA/2JR3/+ mice show variable levels of degeneration. Retinas were stained for βGEO activity in the presence of X-Gal. Each retina is taken from a different animal. This series of photomicrographs demonstrates the high degree of variability observed in disease progression in the DBA/2J line, where some animals have virtually no evidence of ganglion cell loss (A), while others have nearly complete cell loss (D). The retinas shown also demonstrate the scoring system used to quantify the βGeo staining patterns observed: (A) represents a score of approximately 1, (B) a score of approximately 2, (C) a score of approximately 3, and (D) a score of approximately 4. Retinas given a score of 5 exhibited no positively staining cells. Bar = 1 mm.

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