Figure 2
From: Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease
Oligonucleotide inhibition of aggregation of mutant Htt fragment. (A) DNA sequence of two G-rich oligonucleotides that form the G-quartet structure. (B) Dot blot analysis of T40216 and T30923 activity on aggregation. The zero (0) hour control represents reactions that were stopped immediately after addition of the protein; 24-hour reactions carried out in the absence of the oligonucleotide and stopped after 24-hours of incubation; Congo red, level of aggregation 24 hours after addition of Congo Red (10 μM).