Figure 2From: Genetic analysis of the GRIK2modifier effect in Huntington's diseaseEvolutionary conservation of the GRIK2 3'UTR region. Plots comparing chimpanzee, dog, rat, mouse, chicken and frog orthologue sequences to the conserved 3'UTR region of human GRIK2 were generated using mVISTA [34-36]. For the human sequence, we chose chr6: 102623080–102624690, comprising 1610 bp sequence downstream from the stop codon, based upon the report of a polyadenylation signal at 1547 bp after the stop codon [29]. The relative location of the polymorphic TAA repeat within the human sequence is shown between vertical lines (from 787 to 828bp). Plots show % identity over a 100 bp window (vertical axis) of chimpanzee (chr5 (Nov 2003): 104613747-104615339), dog (chr12 (July 2004): 62913564-62915139), rat (chr20 (June 2003): 53258651-53260220), mouse (chr10 (May 2004): 49099305-49100874), chicken (chr3 (Feb 2004): 68531473-68532948), and frog (Xenopus tropicalis) (Scaffold-599 (Oct 2004): 27668-29079), respectively, relative to the human sequence (horizontal axis) [18].Back to article page