TY - JOUR AU - Zeng, Wenqi AU - Gillis, Tammy AU - Hakky, Michael AU - Djoussé, Luc AU - Myers, Richard H. AU - MacDonald, Marcy E. AU - Gusella, James F. PY - 2006 DA - 2006/09/07 TI - Genetic analysis of the GRIK2modifier effect in Huntington's disease JO - BMC Neuroscience SP - 62 VL - 7 IS - 1 AB - In Huntington's disease (HD), age at neurological onset is inversely correlated with the length of the CAG trinucleotide repeat mutation, but can be modified by genetic factors beyond the HD gene. Association of a relatively infrequent 16 TAA allele of a trinucleotide repeat polymorphism in the GRIK2 3'UTR with earlier than expected age at neurological onset has been suggested to reflect linkage disequilibrium with a functional polymorphism in GRIK2 or an adjacent gene. SN - 1471-2202 UR - https://doi.org/10.1186/1471-2202-7-62 DO - 10.1186/1471-2202-7-62 ID - Zeng2006 ER -