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Figure 3 | BMC Neuroscience

Figure 3

From: Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays

Figure 3

TBS-induced LTP in hippocampal slices from 129S5 mice recorded by 8 × 8 3D MEAs. A) Exemplar records of fEPSPs were obtained shortly before and 60 min after induction of LTP (blue and red traces respectively) from five CA1 locations spatially similar to those, outlined in Fig. 1A. LTP was induced by three trains of TBS with intra-train interval of 20 s. There were four pulses at 100 Hz within a burst and 10 bursts delivered at 5 Hz per train. Stimulus strength originally set at evoking 40% of the maximal proximal fEPSP was increased to 125% during TBS. Note a pronounced potentiation of proximal fEPSP (electrode 4) in the absence of fully blown population spike in SP/SO. Slight potentiation of fEPSP was observed in the middle of SR (electrode 3) and no potentiation was seen in distal apical dendrites (electrode 2). In SLM, fEPSPs were small, so indistinctive changes were seen upon LTP induction (electrode 1). Photo of the slice from this experiment as well as waveforms of its responses to maximal stimulation can be found in the Additional file 1. B) Summary LTP data obtained while recording simultaneously in three locations in SR in 13 slices from 129S5 mice. Only the upper part of the S.D. error bar is shown for clarity.

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