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Figure 8 | BMC Neuroscience

Figure 8

From: Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells

Figure 8

Multiple signaling pathways are involved in the survival effect of IGF-1 in PC12 cells. Following treatment with different kinase inhibitors for 40 min, PC12 cells were exposed to 10 nM IGF-1 for 24 hours and cell viability was determined by MTT as described in Methods. Cell survival of PC12 cells induced by IGF-1 is partially inhibited by various blockers, the PI3K inhibitor being the most effective. Data represent assays from at least three independent experiments.

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BMC Neuroscience

ISSN: 1471-2202

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