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Figure 6 | BMC Neuroscience

Figure 6

From: Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells

Figure 6

PMA attenuated the phosphorylation of IGF-1-induced activation of Akt while enhancing the phosphorylation of CREB. PC12 cells were treated with 400 nM PMA before incubation with 10 nM IGF-1 and the phosphorylation of Akt and CREB determined. PMA treatment decreased the phosphorylation of Akt while increasing the activation of CREB. Blots represent prototypical example of experiments replicated at least 3 times.

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BMC Neuroscience

ISSN: 1471-2202

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