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Figure 5 | BMC Neuroscience

Figure 5

From: Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells

Figure 5

The p38 MAP kinase is involved in the phosphorylation of CREB induced by IGF-1 in PC12 cells. PC12 cells were treated with the p38 MAPK inhibitor PD169316 (2.5–20 μM) and 10 nM IGF-1, and the phosphorylation of CREB and p38 MAPK were measured by Western blot with anti-phospho-CREB and phospho-p38MARK antibodies. PD 169316 significantly blocked the phosphorylation of p38 MAPK and CREB induced by IGF-1. Blots represent prototypical example of experiments replicated at least 3 times.

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