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Figure 1 | BMC Neuroscience

Figure 1

From: Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells

Figure 1

IGF-1 induced time- and concentration-dependent phosphorylation of Akt and CREB in PC12 cells. PC12 cells were treated with 10 nM IGF-1 for various times and then the phosphorylation of Akt and CREB were determined as described in Methods. A). Time-dependence and (B). Concentration-dependence. Blots represent prototypical examples of experiments replicated at least 3 times.

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