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Figure 4 | BMC Neuroscience

Figure 4

From: Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys

Figure 4

High external calcium partly reverses isoflurane depression of EPSPs. (Top) control EPSP pairs at left show the first EPSP amplitude (dashed line) and facilitation of the second EPSP (solid line). The center trace shows depression of both EPSPs in the presence of 350 μM isoflurane. The traces at right show reversal of isoflurane depression for the first EPSP and partly for the second in the presence of 350 μM isoflurane and ACSF with [Ca2+] doubled to 4 mM. (Lower Left) bar graph shows reversal of isoflurane (ISF) depression of the first EPSP. The first EPSP amplitude was depressed ~50% by isoflurane, but increased significantly when isoflurane was delivered in ACSF containing 4 mM Ca2+ (ANOVA, p < 0.001, n = 6). (Lower Right) bar graph shows that facilitation tended to increase in the presence of isoflurane but was then significantly depressed when isoflurane was delivered in ACSF containing 4 mM Ca2+ (ANOVA, p < 0.01, n = 6).

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