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Figure 4 | BMC Neuroscience

Figure 4

From: Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

Figure 4

Effect of calpain and caspase inhibitors on glutamate-induced cell death in primary cortical cells. Primary cortical cells isolated from 18 day old fetal rat brains were cultured for 7–8 days and treated with 1 mM glutamate alone or in the presence of the optimal concentration of 12.5 μM calpain inhibitor ALLN and 50 μM z-DEVD caspase-3 inhibitor. LDH release (% maximum) was measured after 6 hrs of treatment *P < 0.05 compared to control; † P < 0.05 compared to glutamate alone.

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BMC Neuroscience

ISSN: 1471-2202

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