Postsynaptic G-protein inactivation does not inhibit synaptic depression. 100 bursts were applied to auditory or trigeminal afferent fibers. Compared to cEPSC1 (control), the burst sequences induced synaptic depression to about 60 % of initial amplitude (SD). This was also true for giant neurons that had been perfused with β-GDP using the patch pipette (SD β-GDP). cEPSC 91–100 were averaged for each cell, the number of cells is indicated for each group. Error bars indicate the standard error between cells.