Post-lesion over-expression of Cu/Zn SOD increases neuronal survival. Nissl stained sections showing the lesion distribution in the animals post-injected with saline (NMDA+saline), NLSCt+Cu/Zn SOD (NMDA+SOD), or NLSCt+GFP (NMDA+GFP)(A). Quantification of Nissl stained neurons in the sensorimotor cortex and hippocampal CA1 penumbra showed increased cell survival in Cu/Zn SOD overexpressing animals (B). GFP overexpressing animals only showed an increase in neuronal number in hippocampal CA1 at a greater distance from the lesion point (B). Degenerating neurons were stained with Fluoro-Jade B staining (C), and quantitative analysis showed a significant reduction of degenerating neurons in Cu/Zn SOD overexpressing animals (D). (*p < 0.05 in relation to NMDA+saline injected animals and #p < 0.05 in relation to NMDA+GFP injected animals).