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Table 4 [3H]-QNB binding constants in cerebellar and hippocampal membranes after administration of a convulsant (7.5 mg/kg) BIC dose.

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area Condition Kd (pM) Δ (%) Bmax (pmol.mg prot-1) NH
Cerebellum Control 200.1 ± 7.1   0.35 ± 0.01 1.00 ± 0.01
  Convulsive 133.3 ± 7.5*** - 33 0.42 ± 0.07 1.05 ± 0.02
Hippocampus Control 108.8 ± 2.7   1.75 ± 0.08 1.01 ± 0.06
  Convulsive 185.6 ± 3.9*** + 85 1.72 ± 0.11 0.98 ± 0.02
  1. For each experiment, cerebellum and hippocampus from five rats were pooled, membranes separated and [3H]-QNB binding assayed. Data from three experiments were processed to calculate constants. Results presented are mean values ± S.D.
  2. *** P < 0.001 (Student-t test).