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Table 3 [3H]-QNB binding constants in cerebellar and hippocampal membranes after administration of a subconvulsant BIC dose (1.0 mg/kg).

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area

Condition

Kd (pM)

Δ (%)

Bmax (pmol.mg prot-1)

NH

Cerebellum

Control

197.5 ± 6.0

 

0.36 ± 0.08

1.01 ± 0.02

 

Subconvulsive

144.9 ± 5.5***

- 27

0.42 ± 0.07

0.98 ± 0.03

Hippocampus

Control

115.4 ± 5.8

 

2.31 ± 0.09

0.97 ± 0.04

 

Subconvulsive

185.6 ± 3.9***

+ 61

2.38 ± 0.10

0.96 ± 0.02

  1. For each experiment, cerebellum and hippocampus from five rats were pooled, membranes separated and [3H]-QNB binding assayed. Data from three experiments were processed to calculate constants. Results presented are mean values ± S.D.
  2. *** P < 0.001 (Student's-t test).
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BMC Neuroscience

ISSN: 1471-2202

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