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Table 3 [3H]-QNB binding constants in cerebellar and hippocampal membranes after administration of a subconvulsant BIC dose (1.0 mg/kg).

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area Condition Kd (pM) Δ (%) Bmax (pmol.mg prot-1) NH
Cerebellum Control 197.5 ± 6.0   0.36 ± 0.08 1.01 ± 0.02
  Subconvulsive 144.9 ± 5.5*** - 27 0.42 ± 0.07 0.98 ± 0.03
Hippocampus Control 115.4 ± 5.8   2.31 ± 0.09 0.97 ± 0.04
  Subconvulsive 185.6 ± 3.9*** + 61 2.38 ± 0.10 0.96 ± 0.02
  1. For each experiment, cerebellum and hippocampus from five rats were pooled, membranes separated and [3H]-QNB binding assayed. Data from three experiments were processed to calculate constants. Results presented are mean values ± S.D.
  2. *** P < 0.001 (Student's-t test).