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Table 2 Effect of a convulsant BIC dose (7.5 mg/kg, i.p.) on [3H]-QNB binding to membranes isolated from brain areas.

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area [3H]-QNB binding
  Control pmol.mg protein-1 Condition Convulsive pmol.mg protein-1 Δ (%)
Cerebellum 0.34 ± 0.03 (6) 0.46 ± 0.03*** (6) + 36
Hippocampus 1.55 ± 0.07 (6) 1.36 ± 0.08** (6) - 12
Striatum 1.98 ± 0.11 (3) 2.27 ± 0.14* (3) + 15
Cerebral cortex 1.35 ± 0.04 (3) 1.42 ± 0.04 (3) + 5
  1. Values are means ± S.D. Figures in parentheses denote number of separate experiments performed in triplicate.
  2. * P < 0.05, ** P < 0.01, *** P < 0.001 (Student's-t test).