Table 2 Effect of a convulsant BIC dose (7.5 mg/kg, i.p.) on [3H]-QNB binding to membranes isolated from brain areas.
From: Convulsant bicuculline modifies CNS muscarinic receptor affinity
Area | [3H]-QNB binding | ||
|---|---|---|---|
|  | Control pmol.mg protein-1 | Condition Convulsive pmol.mg protein-1 | Δ (%) |
Cerebellum | 0.34 ± 0.03 (6) | 0.46 ± 0.03*** (6) | + 36 |
Hippocampus | 1.55 ± 0.07 (6) | 1.36 ± 0.08** (6) | - 12 |
Striatum | 1.98 ± 0.11 (3) | 2.27 ± 0.14* (3) | + 15 |
Cerebral cortex | 1.35 ± 0.04 (3) | 1.42 ± 0.04 (3) | + 5 |