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Table 1 Effect of a subconvulsant BIC dose (1.0 mg/kg, i.p.) on [3H]-QNB binding to membranes isolated from four brain areas.

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area [3H]-QNB binding
  Control pmol.mg protein-1 Condition Subconvulsive pmol.mg protein-1 Δ (%)
Cerebellum 0.35 ± 0.04 (3) 0.50 ± 0.04** (3) + 43
Hippocampus 1.50 ± 0.03 (3) 1.35 ± 0.03* (3) - 10
Striatum 1.98 ± 0.11 (3) 2.09 ± 0.05 (3) + 6
Cerebral cortex 1.35 ± 0.04 (3) 1.44 ± 0.14 (3) + 7
  1. Values are means ± S.D. Figures in parentheses denote number of separate experiments performed in triplicate.
  2. * P < 0.05, ** P < 0.01 (Student's-t test).