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Table 1 Effect of a subconvulsant BIC dose (1.0 mg/kg, i.p.) on [3H]-QNB binding to membranes isolated from four brain areas.

From: Convulsant bicuculline modifies CNS muscarinic receptor affinity

Area

[3H]-QNB binding

 

Control pmol.mg protein-1

Condition Subconvulsive pmol.mg protein-1

Δ (%)

Cerebellum

0.35 ± 0.04 (3)

0.50 ± 0.04** (3)

+ 43

Hippocampus

1.50 ± 0.03 (3)

1.35 ± 0.03* (3)

- 10

Striatum

1.98 ± 0.11 (3)

2.09 ± 0.05 (3)

+ 6

Cerebral cortex

1.35 ± 0.04 (3)

1.44 ± 0.14 (3)

+ 7

  1. Values are means ± S.D. Figures in parentheses denote number of separate experiments performed in triplicate.
  2. * P < 0.05, ** P < 0.01 (Student's-t test).