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Table 1 Comparison of the affinities (Ki values, nM) of various receptor antagonists at dopamine D2 and D4 receptors with their protective effects (at 10-6M) on hippocampal neurons (expressed in % of MTT values vs control group).

From: Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation

  D2 subtype Affinity (Ki, nM) D4 subtype Affinity (Ki, nM) Neuroprotective activity (% vs control, MTT values)
(+)-butaclamol 0.8 40 464
Clozapine 36–190 1.6–40 340
Chlorpromazine 0.66–1.5 1.15–37 320
Domperidone 0.30 ND 299
Haloperidol 0.35–1 0.84–5.1 271
(±)-sulpiride a 9.2–15 52–1000 199
L-741,742 > 1700 3.5 186
Risperidone 0.3–5.9 0.25–16 162
Haloperidol metabolite > 10000 ND 108
Raclopride 0.64–1.8 237–620 110
Remoxipride 30–2000 2800–3690 108
U 99194 2281 > 10000 100
  1. Data from [30-32, 39-45]. ND, not determined.
  2. a S-(-)-sulpiride.