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Figure 2 | BMC Neuroscience

Figure 2

From: Role of the ERK pathway in psychostimulant-induced locomotor sensitization

Figure 2

Effects of SL327 on the locomotor activity induced by injection of D-amph or cocaine. Mice pre-treated with vehicle or SL327 (15, 30 and 50 mg/kg) were injected 30 min later with D-amph (2 mg/kg i.p., A, B) or cocaine (20 mg/kg i.p., C, D). A) Time course of D-amph-induced locomotor activity measured every 5 min is illustrated for mice pre-treated by Vehicle (Veh) or the highest doses of SL327 (30 mg/kg or 50 mg/kg) (10 mice per group). Time course obtained with 15 mg/kg SL327 that was similar to that obtained with 30 mg/kg SL327 is not shown for improving legibility of the figure. Data (30 and 50 mg/kg SL327 and vehicle) were analyzed with a mixed factor ANOVA (repeated measure over time) (effect of SL327 F(2,216) = 43.55, P < 0.01). B) Total locomotor activity during the first hour after D-amph administration was analyzed with one-way ANOVA (F(3,36) = 5.277, P < 0.01). * P < 0.01 Vehicle (Veh) vs SL327 (50 mg/kg). C) Time course of cocaine-induced locomotor activity measured every 5 min for mice pre-treated by Vehicle (Veh) or SL327 (30 mg/kg or 50 mg/kg) (10 mice per group). Time course obtained with 15 mg/kg SL327 was similar to that obtained with 30 mg/kg SL327 (not shown in the figure). Data (30 and 50 mg/kg SL327 and vehicle) were analyzed with a mixed factor ANOVA (repeated measure over time) (effect of SL327 F(2,216) = 12.745, P < 0.05). D) Total locomotor activity during the first hour after cocaine administration was analyzed with one-way ANOVA (F(3,36) = 1.058, NS).

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