Morris water maze task of ADAM11-deficient mice. (A) Escape latencies (sec) in the hidden platform task over nine testing days. Asterisk: significant (p < 0.05) difference from (+/+) mice. (B) The probe test after the acquisition trials of the hidden platform task. Times spent in each quadrant of the water pool are shown. Asterisk: significant (p < 0.05) difference from (+/+) mice. TQ, training quadrant; AR, adjacent right quadrant; AL, adjacent left quadrant; OP, opposite quadrant. (C) Swimming distances (cm) during the probe test. (D) Escape latencies (sec) in the visible platform task over three testing days. +/+, +/- and -/-; n = 11, 14 and 12, respectively.