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Figure 4 | BMC Neuroscience

Figure 4

From: Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus

Figure 4

PACAP enhanced AMPA- and NMDA-evoked Ca2+ responses in a subset of mouse SCN neurons. Optical imaging techniques were used to estimate Ca2+ responses to AMPA and NMDA in ventral SCN neurons during the night (ZT 15–17). (A) AMPA (25 μM)-induced Ca2+ transients were also enhanced by the pre-treatment with PACAP (10 nM, 240 sec). (B) NMDA (25 μM)-induced Ca2+ transients were also enhanced by the pre-treatment with PACAP (10 nM, 240 sec). (C) Histograms summarizing PACAP modulation of AMPA and NMDA-evoked Ca2+ transients in the SCN. The enhancement of AMPA-evoked Ca2+ transients was mimicked by the PAC1 receptor agonist maxadilan (Max, 100 nM, 240 sec). This data was collected in the presence of TTX. Asterisks indicate values that are significantly greater than those of the AMPA- or NMDA-treated groups (P < 0.05)

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