Figure 2

Parkin-deficient mice are not more sensitive to METH toxicity. The hyperthermic response to METH treatment at A. 2.5 mg/kg and B. 5.0 mg/kg was indistinguishable between WT (filled square symbols) and KO (open circle symbols) mice. Body temperature (°C) was measured before METH treatment (time = 0 hr) and every hour thereafter. C. There was no difference between WT and KO mice in the depletion of striatal dopamine (DA) levels (expressed as ng/mg protein) following METH treatment. D. There was also no difference in the reduction of striatal DAT levels following METH treatment (data are expressed in arbitrary units after normalization to WT levels). The numbers of mice used for each genotype are indicated in the figure. Data are expressed as mean ± SEM.