IL-1β regulation by lesion and estrogen treatment: Olfactory bulb lesions significantly increased local IL-1β expression at 6 and 24 hours post injury (6 hpi, 24 hpi). Estrogen treatment (OVX+E) attenuated IL-lβ at 6 hpi, and this effect was more pronounced at 24 hpi. At 24 hpi, anti-p75NTR treatment abolished estrogen's effects on IL-1β. Anti-p75NTR had no effect on IL-1β expression in control pellet-replaced (OVX) animals. Bars represent means ± SEM, n = 6 per group. Sham: Sham lesion, Lesion+Vehicle: NMDA injection with pre immune serum, Lesion+Anti p75: NMDA injections with anti p75NTR antibodies. *:p < 0.05.