Figure 7

Genes that interact genetically with lin-12 to regulate reversals. A. lag-1 and lag-2 likely function with lin-12 to regulate reversals. Complete loss of function in lag-1 and lag-2 cause lethality; therefore, partial loss of function alleles were used (om13 and q420, respectively). lag-2(sd) is lag-2(sa37), a semidominant suppressor of lin-12 gain of function. B. The AMPA/kainate glutamate receptor glr-1 genetically interacts with lin-12. glr-1(lf) is glr-1(n2461), a genetic null allele. glr-1p::glr-1(OE) is nuIs25 (see Methods for details). *** p<0.001 vs. wild type.