Table 1 Genes affected in glutamate receptor expression/localization mutants. Complete list of the mutants identified in the screen. Table 1 lists all of the mutants identified in the screen, organized by putative function of the protein encoded by the gene in which the transposon is inserted. The qualitative glutamate receptor phenotype in the Drosophila mutants is indicated by an arrow pointing upwards (for an increase in immunocytochemically detectable GluRIIA) or downwards (for a decrease in immunocytochemically detectable GluRIIA). The third column lists the Drosophila gene that is mutated by the transposon insertion; superscript letters represent complementation test results: 'f' = transposon insertion failed to complement a deficiency covering the region, and 'c' = insertion complemented a deficiency. Note that the confirmed presence of a background lethal mutation (denoted by 'c') does not indicate whether the NMJ phenotype is also complemented. The fourth column lists the mouse homolog, as determined by best BLAST match to an annotated gene in the mus musculus refseq database.

Extracellular matrix

P{SUPor-P}CG18819 [KG01657]

↓

CG32814

mucin

P{SUPor-P}CG14713 [KG05924]

↓

CG14713

mucin

Cell adhesion

P{SUPor-P}mys [KG02930]

↓

mys

beta integrin

P{SUPor-P}KG00212

↑

Nrt

neuroligin

Cytoskeleton, cytoskeletal regulators, and adaptor proteins

P{SUPor-P}CG10540 [KG02261]

↓

CG10540 ^c

actin capping protein

P{SUPor-P}KG01009

↓

Tkr

actinfilin

P{SUPor-P}pnut [KG00478]

↑

pnut ^f

septin

P{SUPor-P}didum [KG04384]

↓

didum ^c

myosin V

P{SUPor-P}neb [KG05913]

↓

neb ^f

kinesin

P{SUPor-P}KG05547

↓

Cdic

dynein intermediate chain

P{SUPor-P}CG2095 [KG02723]

↓

CG2095 ^f

sec 8

P{SUPor-P}lap [KG06751]

↓

lap

synaptosomal protein 91

P{SUPor-P}noodle [KG03815]

↓

CG3210

dynamin

Kinases & Phosphatases

P{SUPor-P}KG06341

↓

KP78a ^f

MAP/MT affin.-reg. kinase

P{SUPor-P}SNF4Aγ [KG00325]

↓

SNF4γ

AMP-activated kinase

P{SUPor-P}trbl [KG02308]

↓

trbl

AMP-activated kinase

P{SUPor-P}KG04591

↑

CG15072 ^c

SNF-like kinase

P{SUPor-P}KG02006

↓

Rheb

RAS-homolog

P{SUPor-P}polo [16-1]

↓

polo

polo-like kinase

P{SUPor-P}KG00853

↓

CG10082 ^c

inositol hexaphosphate kin.

P{SUPor-P}CG32666 [KG03058]

↓

CG32666

serine-threonine kinase

P{SUPor-P}KG00564

↓

ia2

rec. tyrosine phosphatase

P{SUPor-P}l(1)G0003 [KG02485]

↓

l(1)G003 ^f

Rab coupling protein

Ubiquitination

P{SUPor-P}Cbl [KG03080]

↓

Cbl

E3 ubiquitin ligase

P{GT1}sina [BG02648]

↓

sina

sina (ubiquitin ligase)

Transporters

P{SUPor-P}CG5802 [KG01634]

↑

CG5802 ^f

UDP-galactose translocator

P{SUPor-P}KG02272

↓

CG8029 ^f

lysosomal H+ ATPase

P{SUPor-P}Vha44 [KG00915]

↓

Vha44

vacuolar H+ ATPase

Unknown

P{SUPor-P}oaf [KG03408]

↑

oaf ^c

D130038B21 RIKEN cDNA

P{SUPor-P}KG03591

↓

CG32345

hyp. Protein XP_355833

P{SUPor-P}cmp44E [KG03925]

↓

cmp44E ^c

'similar to KIAA0953'

P{SUPor-P}CG2185 [KG02712]

↑

CG2185

calcium binding P22

P{SUPor-P}KG00333

↓

CG15358

cd209e antigen

P{SUPor-P}CG31694 [KG04350]

↑

CG31694 ^f

interferon development reg.

P{GT1}l(2)35Di [BG02008]

↓

l(2)35Di ^c

[none]

P{SUPor-P}KG06339

↓

[none]

Enzymes

P{SUPor-P}CG4825 [KG06018]

↓

CG4825

phosphatidylserine synth.

P{SUPor-P}TppII [KG03294]

↓

TppII ^c

tripeptidyl peptidase II

Gene expression & Translation

P{SUPor-P}KG02920

↓

hsrω ^f

ladybird homeobox-1-like

P{SUPor-P}KG02514

↓

hbn

aristaless-rel. homeobox

P{SUPor-P}KG03852

↓

Ntf-2

nuclear transport factor-2

P{SUPor-P}Trn-SR [KG04870]

↓

CG2848

transportin 3

P{GT1}CG10689 [BG01776]

↓

CG10689

DEAH box polypeptide

P{SUPor-P}CG11107 [KG02727]

↓

CG11107

DEAH box polypeptide

P{SUPor-P}pnt [KG04968]

↓

pnt

avian leukemia oncogene

P{SUPor-P}KG00625

↓

CG18591

snrpE

P{SUPor-P}RpL3 [KG05440]

↓

RpL3 ^f

ribosomal protein L3

P{SUPor-P}KG03101

↓

Ef2b

translation elong. factor 2

P{SUPor-P}crp [KG00953]

↓

crp

transcription factor AP-4

P{SUPor-P}E2f [KG03332]

↑

E2f

E2f transcription factor

P{SUPor-P}armi [KG04664]

↓

armi ^c

Moloney leukemia virus 10

P{SUPor-P}vri [KG01220]

↑

vri

interleukin3 reg. nuc. factor

P{SUPor-P}Kr-h1 [KG00354]

↓

Kr-h

zinc finger protein

P{SUPor-P}Bgb [KG03779]

↓

Bgb

core binding factor beta

P{SUPor-P}KG06256

↓

Chro ^c

Domino (histone deactyl.)

P{SUPor-P}Chro [KG03258]

↓

Chro

Domino (histone deactyl.)

P{SUPor-P}EcR [KG04522]

↓

EcR

nuclear receptor 1, group H