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Table 1 TMS mapping results. Mean ± standard deviation for the different TMS parameters assessed before and after one hour of synchronized movements of the right thumb and shoulder under different conditions

From: The NMDA antagonist memantine affects training induced motor cortex plasticity – a study using transcranial magnetic stimulation [ISRCTN65784760]

  Single dosage (n= 8)
  Placebo Memantine
  Before training After training Before training After training
x coordinate COG (cm) 1.58 ± 0.61 1.59 ± 0.67 1.43 ± 0.72 1.58 ± 0.62
y coordinate COG (cm) -4.82 ± 0.44 -4.74 ± 0.41 -4.98 ± 0.56 -4.97 ± 0.65
Motor threshold (%) 34.6 ± 3.0 34.1 ± 2.7 35.0 ± 1.7 34.4 ± 1.9
Area (cm2) 14.6 ± 4.4 13.8 ± 2.8 15.5 ± 5.2 16.1 ± 2.8
Sum of amplitudes (μV) 1584.6 ± 999.6 1412.0 ± 797.8 2022.4 ± 1193.6 1733.0 ± 756.6
Number of "hotspots" 3.4 ± 2.4 2.7 ± 2.6 4.2 ± 2.8 3.4 ± 2.3
Mean amplitude (μV) 116.1 ± 94.9 100.4 ± 49.9 161.9 ± 180.6 111.4 ± 53.9
  Ascending dosage over 8 days (n = 7)
  Placebo Memantine
  Before training After training Before training After training
x coordinate COG (cm) 1.21 ± 0.60 1.38 ± 0.59 1.49 ± 0.64 1.53 ± 0.66
y coordinate COG (cm) -5.46 ± 0.69 -5.34 ± 0.61 -5.36 ± 0.50 -5.44 ± 0.59
Motor threshold (%) 40.6 ± 7.1 39.7 ± 6.5 41.3 ± 7.3 40.9 ± 7.0
Area (cm2) 16.6 ± 3.8 15.7 ± 3.6 15.9 ± 3.6 16.3 ± 3.7
Sum of amplitudes (μV) 1901.6 ± 1515.8 1535.1 ± 939.3 1744.4 ± 1086.0 1726.7 ± 808.6
Number of "hotspots" 4.4 ± 3.5 3.6 ± 2.6 3.9 ± 3.1 3.6 ± 2.8
Mean amplitude (μV) 120.5 ± 95.4 104.3 ± 65.0 107.2 ± 52.7 107.6 ± 45.2
  Low dosage (10 mg/d) over 8 days (n = 5)
    Memantine
    Before training After training
x coordinate COG (cm)    0.80 ± 0.46 0.62 ± 0.71
y coordinate COG (cm)    -5.12 ± 0.46 -5.20 ± 0.53
Motor threshold (%)    38.4 ± 8.3 38.8 ± 12.1
Area (cm2)    12.0 ± 4.1 14.6 ± 4.0
Sum of amplitudes (μV)    1852.2 ± 2169.4 1984.6 ± 1686.1
Number of "hotspots"    3.8 ± 3.8 4.0 ± 4.3
Mean amplitude (μV)    131.2 ± 106.1 122.0 ± 92.5