Table 1 TMS mapping results. Mean ± standard deviation for the different TMS parameters assessed before and after one hour of synchronized movements of the right thumb and shoulder under different conditions

1.58 ± 0.61

1.59 ± 0.67

1.43 ± 0.72

1.58 ± 0.62

-4.82 ± 0.44

-4.74 ± 0.41

-4.98 ± 0.56

-4.97 ± 0.65

34.6 ± 3.0

34.1 ± 2.7

35.0 ± 1.7

34.4 ± 1.9

14.6 ± 4.4

13.8 ± 2.8

15.5 ± 5.2

16.1 ± 2.8

1584.6 ± 999.6

1412.0 ± 797.8

2022.4 ± 1193.6

1733.0 ± 756.6

3.4 ± 2.4

2.7 ± 2.6

4.2 ± 2.8

3.4 ± 2.3

116.1 ± 94.9

100.4 ± 49.9

161.9 ± 180.6

111.4 ± 53.9

Ascending dosage over 8 days (n = 7)

Placebo

Memantine

Before training

After training

Before training

After training

1.21 ± 0.60

1.38 ± 0.59

1.49 ± 0.64

1.53 ± 0.66

-5.46 ± 0.69

-5.34 ± 0.61

-5.36 ± 0.50

-5.44 ± 0.59

40.6 ± 7.1

39.7 ± 6.5

41.3 ± 7.3

40.9 ± 7.0

16.6 ± 3.8

15.7 ± 3.6

15.9 ± 3.6

16.3 ± 3.7

1901.6 ± 1515.8

1535.1 ± 939.3

1744.4 ± 1086.0

1726.7 ± 808.6

4.4 ± 3.5

3.6 ± 2.6

3.9 ± 3.1

3.6 ± 2.8

120.5 ± 95.4

104.3 ± 65.0

107.2 ± 52.7

107.6 ± 45.2

Low dosage (10 mg/d) over 8 days (n = 5)

Memantine

Before training

After training

0.80 ± 0.46

0.62 ± 0.71

-5.12 ± 0.46

-5.20 ± 0.53

38.4 ± 8.3

38.8 ± 12.1

12.0 ± 4.1

14.6 ± 4.0

1852.2 ± 2169.4

1984.6 ± 1686.1

3.8 ± 3.8

4.0 ± 4.3

131.2 ± 106.1

122.0 ± 92.5