Skip to main content
Figure 4 | BMC Neuroscience

Figure 4

From: Protection of cortical cells by equine estrogens against glutamate-induced excitotoxicity is mediated through a calcium independent mechanism

Figure 4

Effect of estrogen on glutamate-induced cell death. Neuronal cells were maintained for 6 days under conditions similar to those described under Figure 1. Cells were treated with various concentrations of 17β-E2 and Δ8, 17β-E2. After 24 hrs cells were treated with 200 μM glutamate for 20 mins. Cell viability was measured 24 hrs later. Results are expressed as increase in percent protection compared to glutamate alone. Solid bars represent 17β-E2. Hatched bars represent Δ8, 17β-E2. a. p < 0.05, between glutamate alone and estrogen treatment. b. p < 0.05, between 17β-E2 and Δ8, 17β-E2. Each experiment was repeated a minimum of 6 times with 8 replicates per experiment. Error bars represent SEM.

Back to article page