Figure 3

Quantitative analysis of excitotoxicity-induced changes in the germinative zones. Mean values of the number of BrdU+ cells in the SVZ (a), RMS (b), and DG (c) are shown and compared between intact controls, and lesioned (NMDA injected) contralateral (cl) and ipsilateral (ip) hemispheres. No difference was seen between intact controls and contralateral hemispheres at any time. In the SVZ, there is a significant decrease (asterisk) between the total number of BrdU+ cells in ip hemispheres when compared to cl and control hemispheres at all time points except 40 days post lesion. In the RMS, a significant decrease (asterisk) was seen at 10 hours and 3 days post lesion in NMDA-injected brains when compared to controls. In the DG, no significant difference in BrdU+ cell number was observed at any time point in ip hemispheres were compared to cl or control hemispheres.