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Figure 5 | BMC Neuroscience

Figure 5

From: Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release

Figure 5

Effect of various concentrations of 17β-E 2 and Δ8, 17β-E 2 on glutamate (5 mM) induced cell death in primary cortical cells. Cortical cells isolated from 19 day old fetal rat brains were cultured for 7 days and treated with 5 mM glutamate alone or in the presence of estrogens in neurobasal medium containing 2% antioxidant free B27. LDH release (% maximum) was measured after 6 h treatment. Data are the mean ± SEM values from at least 3 experiments. a = P < 0.05 compared with untreated control cells; b = P < 0.05 compared with glutamate alone.

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