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Figure 10 | BMC Neuroscience

Figure 10

From: Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release

Figure 10

Effects of caspase inhibitors on glutamate-induced cell death in primary cortical cells. Cortical cells isolated from 19 day old fetal rat brains were cultured for 7 days. Cell death was measured by LDH release assay 6 h after incubation with 1 mM glutamate with or without 30 min pretreatment with 100 μM caspase-3 specific inhibitor z-DEVD or a pan-caspase inhibitor z-VAD (A,B,C and D). Inhibitors alone (E and F) or DMSO (G) had not effect on LDH release. Data are the mean ± SEM for 3 experiments performed. a = P < 0.05 compared with control, b = P < 0.05 compared with glutamate alone.

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BMC Neuroscience

ISSN: 1471-2202

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