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Table 1 Genes with significantly changed mRNA levels after BSO treatment. The results were detected by Atlas rat toxicology array II in Ht22 cells treated with 10 mM BSO for 15 hours.

From: The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO)

Protein/gene   Normalized Intensity of control Normalized Intensity of BSO sample Ratio
mRNA increased     
heat shock cognate 71-kDa protein (HSC73; HSC70) Y00054 1773 4780 2.70
eukaryotic peptide chain release factor subunit 1 (ERF1); TB3-1; C11 protein [rat homolog of human] M75715 (human) 208 519 2.50
thioredoxin peroxidase 2 (TDPX2); thioredoxin-dependent peroxide reductase 2; heme-binding 23-kDa protein (HBP23) D30035 1710 3989 2.33
78-kDa glucose-regulated protein precursor (GRP78); immunoglobulin heavy chain binding protein (BIP); steroidogenesis-activator polypeptide; HSPA5 M14050 66 154 2.33
60S ribosomal protein L6 (RPL6) X87107 1932 4353 2.25
copper-zinc-containing superoxide dismutase 1 (Cu-Zn SOD1) Y00404 1285 2813 2.19
proliferating cell nuclear antigen (PCNA); cyclin Y00047 1463 3210 2.19
thymosin beta-10 (TMSB10; THYB10); PTMB10 M17698 3545 7637 2.15
high mobility group protein 2 (HMG2) D84418 957 1976 2.06
heat shock 90-kDa protein beta (HSP90-beta); HSP84; HSPCB S45392 7737 15881 2.05
mRNA decreased     
DNA topoisomerase IIB (TOP2B) D14046 4146 1502 0.36
osteopontin M14656 3630 1535 0.42
contrapsin-like protease inhibitor related protein; SPI-3 serine protease inhibitor D00753 13996 5961 0.43