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Table 1 Genes with significantly changed mRNA levels after BSO treatment. The results were detected by Atlas rat toxicology array II in Ht22 cells treated with 10 mM BSO for 15 hours.

From: The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO)

Protein/gene

 

Normalized Intensity of control

Normalized Intensity of BSO sample

Ratio

mRNA increased

    

heat shock cognate 71-kDa protein (HSC73; HSC70)

Y00054

1773

4780

2.70

eukaryotic peptide chain release factor subunit 1 (ERF1); TB3-1; C11 protein [rat homolog of human]

M75715 (human)

208

519

2.50

thioredoxin peroxidase 2 (TDPX2); thioredoxin-dependent peroxide reductase 2; heme-binding 23-kDa protein (HBP23)

D30035

1710

3989

2.33

78-kDa glucose-regulated protein precursor (GRP78); immunoglobulin heavy chain binding protein (BIP); steroidogenesis-activator polypeptide; HSPA5

M14050

66

154

2.33

60S ribosomal protein L6 (RPL6)

X87107

1932

4353

2.25

copper-zinc-containing superoxide dismutase 1 (Cu-Zn SOD1)

Y00404

1285

2813

2.19

proliferating cell nuclear antigen (PCNA); cyclin

Y00047

1463

3210

2.19

thymosin beta-10 (TMSB10; THYB10); PTMB10

M17698

3545

7637

2.15

high mobility group protein 2 (HMG2)

D84418

957

1976

2.06

heat shock 90-kDa protein beta (HSP90-beta); HSP84; HSPCB

S45392

7737

15881

2.05

mRNA decreased

    

DNA topoisomerase IIB (TOP2B)

D14046

4146

1502

0.36

osteopontin

M14656

3630

1535

0.42

contrapsin-like protease inhibitor related protein; SPI-3 serine protease inhibitor

D00753

13996

5961

0.43