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Figure 2 | BMC Neuroscience

Figure 2

From: Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation

Figure 2

Distribution of potential huntingtin aggregation inhibitors in the NCC library. Most compounds show no or little inhibitory effect on huntingtin aggregation. The potential inhibitors are evenly distributed across the whole chemical library. Due to very high background on particular regions of some dot blotting membranes, some compounds (compounds around 200) show a high apparent promotional effect that is artefactual (as shown in ~-70% inhibition). The 8 compounds located in column 5 of plate 9 were missed and were tested in the second screening at 10 μM.

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