Effects of DHPG on Fos-like immunostaining in Caudate-Putamen and Nucleus Accumbens core and shell Mean (±S.E.M.) bilateral number of c-Fos immunoreactive (IR) cells within caudate-putamen (CPu) at coronal levels +1.7 and -0.3 mm (combined) and nucleus accumbens (Nac) core and shell at coronal level +1.5 mm in relation to bregma. Ad libitum fed and food-restricted rats were injected i.c.v. with DHPG (500 nmol) 90 min prior to perfusion. *p < .025, **p < .01 compared to ad libitum fed rats. Representative digital photomicrographs depicting Fos-like immunoreactivity in NAc of ad libitum fed (left) and food-restricted (right) rats are included. LV = lateral ventricle; AC = anterior commissure.