Figure 7From: Bi-directional modulation of AMPA receptor unitary conductance by synaptic activityA model for the mechanisms of DP and de novo LTD. Rectangles represent AMPARs, open circles transmitter vesicles. (A) DP is due to a reduction in the number of surface-expressed AMPARs (DPN) when preceded by LTPN. Depression below the original baseline is due to a further reduction in AMPA receptor number causing a complete loss of postsynaptic receptors at some synapses. De novo LTD [17] is due to the same mechanism. (B) DP is due to a reduction in γ (DPγ) when preceded by LTPγ.Back to article page