Figure 1

Illustrations of Important Simulation Parameters and Quantities Measured. (a) Sketch of constraint region, an angular region of size 2δ centered at the contacting filopodium's initiation angle θ_c, which is created by filopodial contact with a guidance cue. The growth cone cannot migrate into the constraint region. (b) A repulsive cue migration sequence where the growth cone migrates with a pre-contact trajectory angle ζ_pre until it makes filopodial contact with a repulsive cue. The turn angle φ is calculated from the difference between the pre-contact trajectory angle ζ_pre and the post-contact trajectory angle ζ_post.