Figure 4From: Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptorGSK3 inhibitors facilitate Fas-induced apoptosis. (A) Differentiated immortalized hippocampal neurons were pretreated for 30 min with 20 mM lithium, with or without 20 mM myo-inositol, and active caspase-3 and proteolyzed PARP were measured 24 hr with or without Fas stimulation. (B) In Jurkat cells and differentiated immortalized hippocampal neurons, activation of caspase-3 and PARP cleavage induced by Fas stimulation were facilitated following 30 min pretreatment with 20 mM lithium, 5 μM rottlerin (Rott), 20 μM indirubin-3'-monoxime (Ind), or 5 μM kenpaullone (Ken).Back to article page