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Figure 4 | BMC Neuroscience

Figure 4

From: Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor

Figure 4

GSK3 inhibitors facilitate Fas-induced apoptosis. (A) Differentiated immortalized hippocampal neurons were pretreated for 30 min with 20 mM lithium, with or without 20 mM myo-inositol, and active caspase-3 and proteolyzed PARP were measured 24 hr with or without Fas stimulation. (B) In Jurkat cells and differentiated immortalized hippocampal neurons, activation of caspase-3 and PARP cleavage induced by Fas stimulation were facilitated following 30 min pretreatment with 20 mM lithium, 5 μM rottlerin (Rott), 20 μM indirubin-3'-monoxime (Ind), or 5 μM kenpaullone (Ken).

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