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Figure 1 | BMC Neuroscience

Figure 1

From: Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor

Figure 1

Lithium promotes apoptotic signaling mediated by Fas in Jurkat cells. Jurkat cells were pretreated with 20 mM lithium for 30 min as indicated, followed by treatment with an agonistic anti-Fas antibody (5, 10, 20, or 50 ng/ml). After 24 hr, immunoblots were used to detect (A) active caspase-3, and (B) cleaved PARP. Densitometry was used to measure immunoreactive bands and the ratios of the responses in the presence and absence of lithium were calculated (shown under the immunoblots; Mean ± SEM; n = 3).

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