Skip to main content
Figure 1 | BMC Neuroscience

Figure 1

From: Asialoerythropoetin is not effective in the R6/2 line of Huntington's disease mice

Figure 1

No effect of asialoEPO on the decline in rotarod performance or body weight in R6/2 mice. Mice were tested weekly on the rotarod for 3 trials of 180 s each, with the speed of 15 rpm. The value of the mean latency to fall for these three trials was then compared between the mice. The testing began at 5 weeks and continued until 12 weeks of age. The data was analyzed using a two factor repeated measures ANOVA that revealed a significant difference between the groups (F (2, 96) = 16.61, p = 0.0001) and a significant effect of time (F (6, 96) = 4.16, p = 0.0009). However, administration of asialoEPO 3 times weekly from 5 to 12 weeks of age did not significantly affect the decline in rotarod performance in R6/2 mice (A). The mice were also weighed weekly from 5 to 12 weeks of age (B). The data were analyzed using a two factor repeated measures ANOVA that revealed a significant effect of time (F (6, 96) = 1.55, p < 0.0001) and significant difference in the weight over time between the groups (F (12, 96) = 1.32, p < 0.0001). However, there was no effect of asialoEPO on the progressive reduction in body weight in R6/2 mice (F (2, 96) = 1.47, p > 0.05).

Back to article page