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Figure 3 | BMC Neuroscience

Figure 3

From: The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

Figure 3

Relationship between Anoikis (apoptosis due to loss of cell adhesion) and cell surface Fas-expression. (A,C) Sample frequency histograms of PI incorporation (DNA content) in adherent (A) and non-adherent (C) precursors indicates that adherent precursors are mainly in G0, while non-adherent precursors are mainly apoptotic. (B, D) Scatter-plots of combined analysis of PI (x-axis) and cell-surface Fas immunofluorescence (y-axis) indicates that adherent precursors largely express moderate levels of cell-surface Fas (FasMod, B), while non-adherent precursors also express high levels of Fas (FasHi, D). (E) Graph (Mean + SEM) showing that collagenase-A treatment significantly increased the number of cells expressing cell-surface Fas, relative to controls. Asterisk indicates p < 0.05.

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BMC Neuroscience

ISSN: 1471-2202

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