Skip to main content

Table 1 SIV-infected macaque clinical and histopathological data

From: A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS

Animal Sex Survival Age at death SIVE Reason for euthanasia CNS histopathology Non-CNS pathology
530–98 M 523 dpi 1119 days est Y Weight loss; mild diarrhea Moderate SIVE; meningo-encephalomyelitis due to CMV Orchitis due to CMV; enterotyphlocolitis
456–98 F 176 dpi 948 days Y Weight loss; severe diarrhea Mild SIVE SIV giant cell pneumonia and PCP; mild enteritis
526–98 M 153 dpi 756 days est N Weight loss; diarrhea; anorexia Mild perivascular accumulations of macrophages Mild PCP and CMV in lung; glomerulonephritis
520–98 M 293 dpi 1254 days est N Severe oral disease Mild perivascular edema Ulcerative gingivitis and osteomyelitis; myocarditis
202–98 M 742 dpi 1648 days N Epistaxis; respiratory disease No significant CNS pathology Severe PCP
513–98 F 726 dpi 1694 days est N Termination of study No significant CNS pathology Vegetative endocarditis; fibrinous pleuritis
104–98 F 735 dpi 1646 days N Termination of study No significant CNS pathology Mild enteritis
170–98 F 735 dpi 1612 days N Termination of study No significant CNS pathology Vegetative endocarditis; severe protozoal gastritis
  1. SIVE: SIV encephalitis CNS: central nervous system CMV: Cytomegalovirus PCP: Pneumocystis carinii pneumonia dpi: days post-inoculation est: estimated