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Figure 5 | BMC Neuroscience

Figure 5

From: TGF-β1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors

Figure 5

Effect of Smad inhibition on the TGF-β1 activation of Ant1. Primary astrocytes were transiently co-transfected with the TGF-β1 responsive Ant1 485 bp reporter construct and with expression constructs for the indicated dominant negative Smads or empty vector control. Levels of Ant1 promoter activity induction by TGF-β1 in the presence of individual dominant negative Smads and empty vector control were assessed by one-way ANOVA (p < 0.05). Individual dominant negative Smad treatments were compared relative to empty vector control by Dunnett's post hoc multiple comparison test.

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