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Table 2 Steady state inactivation properties of CaV2.1/β4 or CaV2.1/β4/α2δ2 with or without γ2 or γ4

From: Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.

Channel Inactivation n
  V50inact (mV) kinact  
CaV2.1/β4/α2δ2 -31.52 ± 1.58 7.04 ± 0.19 18
CaV2.1/β4/α2δ22 -33.44 ± 1.49 7.10 ± 0.23 18
CaV2.1/β4/α2δ2 -31.40 ± 0.89 7.04 ± 0.28 20
CaV2.1/β4/α2δ24 -34.60 ± 1.43 6.61 ± 0.28 20
CaV2.1/β4 -32.40 ± 1.09 8.43 ± 0.61 22
CaV2.1/β42 -37.30 ± 1.75 7.52 ± 0.74 16
CaV2.1/β44 -31.50 ± 1.80 8.40 ± 0.92 9
  1. Steady-state inactivation data from Figures 7C, 7D and 7E were fitted with a single Boltzmann function (see methods). Values are expressed as mean ± S. E. M. of the number of replicates, n. In the presence of an α2δ2 subunit, neither γ2 nor γ4 caused statistically significant modulation of the measured parameters according to an un-paired Student's t-test (P < 0.05 was considered significant). Equally, when the α2δ2 subunit was omitted from the injection mixture, ANOVA determined no statistically significant changes in any pairs of data differing by the presence of a γ protein.