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Table 1 Characteristics of IBa via CaV2.1/β4 or CaV2.1/β4/α2δ2 with or without γ2 or γ4

From: Human neuronal stargazin-like proteins, γ2, γ3 and γ4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.

Channel Activation   n
  V0.5act(mV) kact. Gmax (μS) Peak at +10 mV (μA)  
CaV2.1/β4 -2.60 ± 0.65 5.39 ± 0.49 8.45 ± 2.20 -0.25 ± 0.05 16
CaV2.1/β42 -4.27 ± 1.24 4.91 ± 0.52 9.96 ± 3.34 -0.32 ± 0.12 14
CaV2.1/β44 -5.70 ± 2.26 5.43 ± 0.47 8.16 ± 2.59 -0.26 ± 0.07 11
CaV2.1/β4/α2δ2 -4.60 ± 0.59 4.03 ± 0.15 14.97 ± 2.05 * -0.54 ± 0.08 43
CaV2.1/β4/α2δ22 -4.13 ± 0.63 4.46 ± 0.14 15.43 ± 1.96 -0.54 ± 0.07 34
CaV2.1/β4/α2δ24 -5.56 ± 0.60 3.96 ± 0.24 14.8 ± 2.64 -0.56 ± 0.10 20
  1. To analyze the voltage-dependent activation, current-voltage (I-V) relationships (Figure 7A and Figure 7B) were fitted with a modified Boltzmann equation (see methods) to calculate V50act, the mid-point of voltage dependence of activation, kact, the slopefactor and Gmax, the maximum conductance. Values are expressed as mean ± S. E. M. of the number of replicates, n. One-way analysis of variance (ANOVA) tests determined no statistically significant changes in any pairs of data differing by the presence of a γ2 or γ4 P < 0.05 was considered significant). Statistically significant differences observed between the CaV2.1/β4 and CaV2.1/β4/α2δ2 channels are indicated by * (P < 0.05).