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Table 1 Effect of RO 25-6981 on clinical parameters in experimental bacterial meningitis

From: Blockade of NMDA receptor subtype NR2B prevents seizures but not apoptosis of dentate gyrus neurons in bacterial meningitis in infant rats

 

Low dosage study

High dosage study

 

0.9% NaCl (250 μl)

RO 25-6981 (15 mg/kg)

0.9% NaCl (250 μl)

RO 25-6981 (150 mg/kg)

Bacteria in CSF (log10 cfu/ml) *

7.4 ± 0.7

7.3 ± 0.4

7.6 ± 0.6

7.8 ± 0.4

Clinical assessment (score) *

3.5 ± 0.8

3.7 ± 0.7

3.3 ± 0.8

3.4 ± 0.8

Mortality (%)

(hours after infection) *

21

21 ± 0.9

14

20.8 ± 1.7

33

21 ± 1.6

53

20.6 ± 1.5

Incidence of seizures (%)

25

11

33

7

  1. Note: * Data are mean ± SD