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Table 1 Effect of RO 25-6981 on clinical parameters in experimental bacterial meningitis

From: Blockade of NMDA receptor subtype NR2B prevents seizures but not apoptosis of dentate gyrus neurons in bacterial meningitis in infant rats

  Low dosage study High dosage study
  0.9% NaCl (250 μl) RO 25-6981 (15 mg/kg) 0.9% NaCl (250 μl) RO 25-6981 (150 mg/kg)
Bacteria in CSF (log10 cfu/ml) * 7.4 ± 0.7 7.3 ± 0.4 7.6 ± 0.6 7.8 ± 0.4
Clinical assessment (score) * 3.5 ± 0.8 3.7 ± 0.7 3.3 ± 0.8 3.4 ± 0.8
Mortality (%)
(hours after infection) *
21
21 ± 0.9
14
20.8 ± 1.7
33
21 ± 1.6
53
20.6 ± 1.5
Incidence of seizures (%) 25 11 33 7
  1. Note: * Data are mean ± SD