Low dosage study | High dosage study | |||
---|---|---|---|---|
0.9% NaCl (250 μl) | RO 25-6981 (15 mg/kg) | 0.9% NaCl (250 μl) | RO 25-6981 (150 mg/kg) | |
Bacteria in CSF (log10 cfu/ml) * | 7.4 ± 0.7 | 7.3 ± 0.4 | 7.6 ± 0.6 | 7.8 ± 0.4 |
Clinical assessment (score) * | 3.5 ± 0.8 | 3.7 ± 0.7 | 3.3 ± 0.8 | 3.4 ± 0.8 |
Mortality (%) (hours after infection) * | 21 21 ± 0.9 | 14 20.8 ± 1.7 | 33 21 ± 1.6 | 53 20.6 ± 1.5 |
Incidence of seizures (%) | 25 | 11 | 33 | 7 |