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Figure 9 | BMC Neuroscience

Figure 9

From: ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

Figure 9

Lysosomes do not actively participate in vacuole formation. Spinal cord sections from SOD1G93A mice were stained with anti-SOD1 (red) and anti-cathepsin D (green) antibodies, and visualized by 3-D reconstruction of confocal images. C and G are superimpositions of the red and green signals. D and H are the same as C and G, respectively, but rotated 30° to the right. Arrows point to small vacuoles that contain SOD1 but not cathepsin D signals. MN marks a motor neuron cell body. Arrows point to small vacuoles. The arrowhead points to SOD1 aggregates.

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