Figure 9From: ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomesLysosomes do not actively participate in vacuole formation. Spinal cord sections from SOD1G93A mice were stained with anti-SOD1 (red) and anti-cathepsin D (green) antibodies, and visualized by 3-D reconstruction of confocal images. C and G are superimpositions of the red and green signals. D and H are the same as C and G, respectively, but rotated 30° to the right. Arrows point to small vacuoles that contain SOD1 but not cathepsin D signals. MN marks a motor neuron cell body. Arrows point to small vacuoles. The arrowhead points to SOD1 aggregates.Back to article page