Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins

Angelastro, James M; Töröcsik, Béata; Greene, Lloyd A

doi:10.1186/1471-2202-3-3

BMC Neuroscience

Table 1 The effect of NGF (9 days treatment) on expression levels of transcripts for various ribosomal proteins in PC12 cell cultures

From: Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins

TAG	RP	ACC#	#TAGS-	#TAGS+	FOLD CHANGE +NGF	P value
GGACCGCTCAA	L3	X62166	44	27	↓ 1.6	0.06
TTGAAGCTGAA	L4/L1	X82180	49	39	↓ 1.3	0.2
CTGCTATCCGA	L5	X06148	40	28	↓ 1.4	0.15
TACCCTCACAA	L6	X87107	16	24	↑ l.5	0.05
AGATCTATACA	L7	Ml 7422	8	7	↓ 1.1	0.5
CACCACTGTTG	L7A	X15013	63	47	↓ 1.3	0.2
AATCCTGTGGA	L8	P25120	119	58	↓ 2.1	0.0002
ATCAAGGGTGT	L9	X51706	7	19	↑ 2.7	0.01
TTCAATAATAA	L10	X87106	24	17	↓ 1.4	0.2
GGCAAGCCCCA	L10A	X93352	26	30	↑ 1.2	0.2
CGCTGGTTCCA	L11	X62146	18	23	↑ .3	0.1
ACATCATAGAT	L12	R7RT12	59	15	↓ 3.9	< 0.0001
GCCCGAGCCAA	L13	X78327	48	57	↑ .2	0.1
AGGTCGGGTGG	L13A	X68282	87	118	↑ 1.3	0.002
AGGAGGCTACA	L14	X94242	31	51	↑ 1.6	0.003
GCACGGGAATA	L17	X58389	8	26	↑ 3.2	0.0007
GGTGTTGACAT	L18	M20156	47	12	↓ 3.9	< 0.0001
AAGGTGGAAGA	L18A	JC4231	56	33	↓ 1.7	0.03
GATCAGTCATT	L19	X82202	65	63	↓ 1.0	0.3
GCCTAATGTAT	L21	M27905	43	32	1.3	0.2
TTTTGTATTAA	L22	X78444	5	4	1.3	0.7
GTGATGGCCAC	L23	X58200	72	63	↓ 1.1	0.4
AAGGTCGAGCT	L24	X78443	95	28	↓ 3.4	< 0.0001
CCCAGTTTTCA	L26	X14671	31	19	↓ 1.6	0.1
CCCACAAGGTA	L27	X07424	16	30	↑ 1.9	0.007
ATCCGAAAAAA	L28	X52619	42	10	↓ 4.2	0.0001
GCCAAGGGTCG	L29	X68283	97	40	↓ 2.4	< 0.0001
CCAGAACAGAC	L30	X52619	36	9	↓ 4.0	0.0002
AAGGAGATGGG	L31	X04809	64	111	↑ 1.7	< 0.0001
CTGCCTAGCGG	L32	X06483	26	20	↓ 1.3	0.2
TGCGCCAAGTG	L34	X14401	27	30	↑ 1.1	0.2
AAGAGAAGCTG	L35	X51705	115	70	↓ 1.6	0.009
GTTCGTGCCAA	L35A	X03475	33	16	↓ 2.1	0.04
CGGAAGGCGGC	L36	X68284	38	77	↑ 2.0	< 0.0001
GATTCCGTGAA	L37	X66369	58	79	↑ 1.4	0.01
AAAACAGTGGC	L37A	X14069	55	90	↑ 1.6	0.0003
TGACTATTAAA	L38	X57007	25	21	↓ 1.2	0.5
TCTTCTCACAA	L39	X82551	15	27	↑ 1.8	0.03
CAGATCTTCGT	L40	X82636	89	32	↓ 2.8	< 0.0001
AGAGCGAAGTG	L41	X82550	185	80	↓ 2.3	< 0.0001
CAAGGTGACAG	S2	U92700	52	47	↓ 1.1	0.4
CCTCAGCCAGT	S3	X51536	21	35	↑ 1.7	0.03
GTGAAGGCGGT	S3A	X75161	46	43	↓ 1.1	0.4
ATGAAATCAAA	S4	X14210	44	20	↓ 2.2	0.01
CCTTTGAGATC	S5	X58465	72	34	↓ 2.1	0.004
GCAGAGTGCGC	S6	NM_017160	63	27	↓ 2.3	0.0006
TTCAGCTCGAG	S7	X53377	41	31	↓ 1.3	0.3
CCCGTGTGCTC	S9	X66370	54	32	↓ 1.7	0.06
CAGTCTCTCAA	S10	X13549	57	36	↓ 1.6	0.02
TCTGTGCACCT	S11	K03250	23	18	↓ 1.3	0.4
TATGTCAAGCT	S12	M18547	92	52	↓ 1.8	0.006
GTGTGGCACAG	S13	X53378	65	65	1.0	0.2
TTGGCTGCCCA	S14	X15040	99	50	↓ 2.0	0.0008
GTGGGTGTGTA	S15	NM_017151	254	60	↓ 4.2	< 0.0001
AAGAGGCAAGA	S15A	X77953	35	48	↑ 1.4	0.04
TGGCCCAAATT	S16	X17665	155	48	↓ 3.2	< 0.0001
GGCCGCGTTCG	S17	K02933	18	39	↑ 2.1	0.003
CAGAACCCACG	S18	X57529	101	26	↓ 3.9	< 0.0001
ACCAAGATCTA	S19	X51707	136	28	↓ 4.8	< 0.0001
CCTACCAAGAC	S20	X51537	8	16	↑ 2.0	0.07
GGTCTGGCTAG	S21	X79059	0	3	↑ 3.0	na
CCGTGGGTGAT	S23	X77398	52	68	↑ 1.3	0.03
GCCTTTATGAG	S24	X52445	310	87	↓ 3.6	< 0.0001
CCGCCCAAAGA	S25	X62482	90	43	↓ 2.1	0.0003
GAAAAATAAAA	S26	X02414	35	16	↓ 2.2	0.03
CACAAACGGTA	S27-1	AF184893	99	46	↓ 2.2	0.0004
GGTAGCCACTT	S27A	X81839	33	77	↑ 2.3	< 0.0001
GAATGACCTGC	S28	X59277	40	37	↓ 1.1	0.4
CTAGTCTTTGT	S29	X59051	125	123	↓ 1.0	0.3
GTTCTCTGGCT	S30	X62671	29	33	↑ 1.2	0.3
GGATTCGGTCT	P0	Z29530	40	55	↑ 1.4	0.04
TCCAATAAAGA	P1	R5RT12	96	48	↓ 2.0	0.0002
GGATTTGGCCT	P2	X15098	83	84	↑ 1.0	0.3
GGAGGTTATGC	40 KD RP	D25224	83	34	↓ 2.4	< 0.0001

Rat SAGE tags and the corresponding ribosomal proteins (and GenBank accession numbers) are given along with the number of times each tag was detected. For cells before and after NGF treatment, a total of 76,280 and 87,004 11 bp tags were analyzed, respectively. Tag numbers for non-treated cultures were normalized against those for NGF treated cultures. P values were calculated by Monte Carlo simulations using SAGE software. Fold changes in which P ≤ 0.01 are expressed in bold.

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