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Table 1 Linkage Statistics for Striatal Volume and Neuron Number

From: Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

Trait Marker Chr LRS† %Var P Add** Dom
Striatal Volume D1Mit15 1 6.3 11 0.04361 1.55 1.19
(mm3) D5Mit338 5 6.4 11 0.03984 -1.00 -2.13
  D6Mit201 6 7.7 14 0.02161 0.90 2.88
  D10Mit106 10 11.4 23 0.00342 2.54 1.09
* D10Mit186 10 17.5 35 0.00016 2.34 1.46
  D10Mit209 10 14.8 30 0.00061 2.15 1.26
  D11Mit263 11 6.6 12 0.03675 1.39 1.67
  D13Mit64 13 7.5 14 0.02330 0.29 2.72
Striatal Volume D10Mit106 10 6.8 12 0.03316 0.71 1.19
Residual D13Mit108 13 6.7 12 0.03496 0.30 1.45
Striatal Neuron D1Mit65 1 9.6 19 0.00809 -57,000 -229,000
Number D10Mit186 10 8.3 16 0.01593 96,000 181,000
  D10Mit209 10 6.8 13 0.03296 86,000 171,000
  D15Mit220 15 8.7 17 0.01275 128,000 177,000
  D19Mit123 19 11.9 24 0.00263 198,000 -126,000
Striatal Neuron D1Mit65 1 7.2 13 0.02697 -33,000 -189,000
Number Residual D13Mit108 13 6.5 11 0.03925 -46,000 173,000
  D15Mit220 15 7.4 14 0.02533 110,000 147,000
  D16Mit130 16 6.8 12 0.03270 -99,000 206,000
* D19Mit123 19 15.0 30 0.00055 201,000 -94,000
Brain Volume D10Mit186 10 12.3 25 0.00217 28.09 8.82
(mm3) D10Mit209 10 10.0 20 0.00672 25.12 5.86
  D10Mit233 10 10.1 22 0.00634 31.30 8.62
  D18Mit20 18 14.8 30 0.00061 36.76 -0.34
  D18Mit120 18 12.2 25 0.00219 28.80 -16.27
Brain-Striatal D10Mit186 10 11.4 23 0.00328 25.8 6.9
Volume D10Mit209 10 9.3 18 0.00965 23.0 4.1
  D10Mit233 10 9.3 20 0.00935 28.5 6.5
  ¶D18Mit20 18 15.1 31 0.00053 34.7 -1.7
  D18Mit120 18 12.8 26 0.00168 27.2 -16.4
  1. ** Alleles inherited from BXD5 that increase a value are defined as positive additive effects. † LRS values can be converted to LOD scores by dividing by 4.6. Previously described QTL for brain weight [56]. Column headings: Trait, the phenotype used in linkage analysis; Marker, the symbol of the microsatellite loci used to genotype mice; Chr, the chromosome on which the marker is located; LRS is the likelihood ratio statistic (4.6 x the LOD score); %Var is the percentage of the total phenotypic variance apparently accounted for by differences in genotype in the an interval defined by the marker; P, the point-wise probability that the linkage is a false positive. Add and Dom are estimates of the additive and dominance effects of genetic variation. Units are the same as those of the traits (volume in mm3 or numbers of cells). The two bold loci marked with asterisks achieve genome-wide significance in this sample population.
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