Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number

BMC Neuroscience

Table 1 Linkage Statistics for Striatal Volume and Neuron Number

Trait	Marker	Chr	LRS†	%Var	P	Add^**	Dom
Striatal Volume	D1Mit15	1	6.3	11	0.04361	1.55	1.19
(mm³)	D5Mit338	5	6.4	11	0.03984	-1.00	-2.13
	D6Mit201	6	7.7	14	0.02161	0.90	2.88
	D10Mit106	10	11.4	23	0.00342	2.54	1.09
^*	D10Mit186	10	17.5	35	0.00016	2.34	1.46
	D10Mit209	10	14.8	30	0.00061	2.15	1.26
	D11Mit263	11	6.6	12	0.03675	1.39	1.67
	D13Mit64	13	7.5	14	0.02330	0.29	2.72
Striatal Volume	D10Mit106	10	6.8	12	0.03316	0.71	1.19
Residual	D13Mit108	13	6.7	12	0.03496	0.30	1.45
Striatal Neuron	D1Mit65	1	9.6	19	0.00809	-57,000	-229,000
Number	D10Mit186	10	8.3	16	0.01593	96,000	181,000
	D10Mit209	10	6.8	13	0.03296	86,000	171,000
	D15Mit220	15	8.7	17	0.01275	128,000	177,000
	D19Mit123	19	11.9	24	0.00263	198,000	-126,000
Striatal Neuron	D1Mit65	1	7.2	13	0.02697	-33,000	-189,000
Number Residual	D13Mit108	13	6.5	11	0.03925	-46,000	173,000
	D15Mit220	15	7.4	14	0.02533	110,000	147,000
	D16Mit130	16	6.8	12	0.03270	-99,000	206,000
^*	D19Mit123	19	15.0	30	0.00055	201,000	-94,000
Brain Volume	D10Mit186	10	12.3	25	0.00217	28.09	8.82
(mm³)	D10Mit209	10	10.0	20	0.00672	25.12	5.86
	D10Mit233	10	10.1	22	0.00634	31.30	8.62
	D18Mit20	18	14.8	30	0.00061	36.76	-0.34
	D18Mit120	18	12.2	25	0.00219	28.80	-16.27
Brain-Striatal	D10Mit186	10	11.4	23	0.00328	25.8	6.9
Volume	D10Mit209	10	9.3	18	0.00965	23.0	4.1
	D10Mit233	10	9.3	20	0.00935	28.5	6.5
	¶D18Mit20	18	15.1	31	0.00053	34.7	-1.7
	D18Mit120	18	12.8	26	0.00168	27.2	-16.4

^** Alleles inherited from BXD5 that increase a value are defined as positive additive effects. † LRS values can be converted to LOD scores by dividing by 4.6. Previously described QTL for brain weight [56]. Column headings: Trait, the phenotype used in linkage analysis; Marker, the symbol of the microsatellite loci used to genotype mice; Chr, the chromosome on which the marker is located; LRS is the likelihood ratio statistic (4.6 x the LOD score); %Var is the percentage of the total phenotypic variance apparently accounted for by differences in genotype in the an interval defined by the marker; P, the point-wise probability that the linkage is a false positive. Add and Dom are estimates of the additive and dominance effects of genetic variation. Units are the same as those of the traits (volume in mm³ or numbers of cells). The two bold loci marked with asterisks achieve genome-wide significance in this sample population.

ISSN: 1471-2202