Interaction diagrams of Propofol with lower binding site (THR361) of 5-HT3A. A. 2-D Ligand interaction diagram. Residues are annotated with their 3-letter amino acid code, and their position classification. Hydrophilic interactions: include the hydroxyl group with residue Asp266 and Met263 (Blue). Hydrophobic interactions: Ile (267, 356, 364, 494), Ser357, Glu360, and Tyr 495 (Red) B. 3-D depiction of interaction.